February 21, 2022 0 Comments

Radiation-induced C–reactive protein triggers apoptosis of vascular smooth muscle cells through ROS interfering with the STAT3/Ref-1 complex TranslateAfrikaansAlbanianAmharicArabicArmenianAzerbaijaniBasqueBelarusianBengaliBosnianБългарскиCatalanCebuano中文(简体)中文(繁體)CorsicanCzechDanishDutchEnglishEsperantoEstonianFinnishFrançaisGeorgianDeutschGreekHaitian CreoleHindiHungarianIcelandicIndonesianIrishItalianJapaneseKazakhKhmerKoreanKyrgyzLaoLatinLatvianLithuanianLuxembourgishMacedonianMalayMalteseMaoriMongolianMyanmar (Burmese)NepaliNorwegianPashtoPersianPolishPortugueseRomanianRussianSamoanSerbianSinhalaSlovakSlovenianSomaliSpanishSwahiliSwedishTajikTamilThaiTurkishUkrainianUrduUzbekVietnameseXhosaZulu Journal: Journal of Cellular and Molecular Medicine February/18/2022 Damage to normal tissue can occur over a long period after cancer radiotherapy. Free radical by radiation can initiate or accelerate chronic inflammation, which can lead to atherosclerosis. However, the underlying …

Chloramphenicol-activated electro-chemiluminescent behavior of BNQDs-Ru(phen)32+ system for ultra-sensitive sensing of chloramphenicol in pharmaceutical and milk samples

February 21, 2022 0 Comments

To improve the sensitivity for electro-chemiluminescent (ECL) detection of chloramphenicol (CAP), a common broad-spectrum antibiotic, boron nitride quantum dots (BNQDs) were prepared with excellent photoelectric property and low toxicity. After its structure and electrochemical property were investigated in detail, it was noted that the ECL signal of Ru(Phen)32+ could be strengthened by the proposed BNQDs, …

The association of basal cortisol levels with episodic memory in older adults is mediated by executive function

February 21, 2022 0 Comments

Elevated basal cortisol levels in elderly may indicate dysregulation of the internal stress-related system, as well as dysfunction and structural alterations in brain structures necessary for cognition, such as hippocampus and prefrontal cortex. Because of the close relation of executive functions and episodic memory processing, in this study we explored whether the association of elevated …

Telomere shortening is associated with corticosterone stress response in adult barn swallows

February 21, 2022 0 Comments

When vertebrates face stressful events, the hypothalamic-pituitary-adrenal (HPA) axis is activated, generating a rapid increase in circulating glucocorticoid (GC) stress hormones followed by a return to baseline levels. However, repeated activation of HPA axis may lead to increase in oxidative stress. One target of oxidative stress is telomeres, nucleoprotein complexes at the end of chromosomes …

Ceruloplasmin Deficiency Impaired Brain Iron Metabolism and Behavior in Mice

February 21, 2022 0 Comments

Iron accumulation is an important cause of various brain diseases. As a ferroxidase, ceruloplasmin (Cp) plays a key role in iron homeostasis and its abnormal activity leads to iron accumulation. However, the detailed biological function of Cp in brain iron homeostasis needs to be investigated. In this study, Cp knockout mice were prepared and the …

Boronate affinity-based template-immobilization surface imprinted quantum dots as fluorescent nanosensors for selective and sensitive detection of myricetin

February 21, 2022 0 Comments

In order to prepare a kind of efficient fluorescence sensors for determination of cis-diol-containing flavonoids, novel imprinted quantum dots for myricetin (Myr) were prepared based on boronate affinity-based template-immobilization surface imprinting. The obtained boronate affinity-based surface imprinted silica (imprinted APBA-functionalized CdTe QDs) was used as recognition elements. The quantum dots were used as signal-transduction materials. …

Synergetic integration of catalase and Fe 3 O 4 magnetic nanoparticles with metal organic framework for colorimetric detection of phenol

February 21, 2022 0 Comments

Toxic phenol pollutants pose a great threat to the environment, it is urgent to develop an efficient and recyclable method to monitor phenol. Herein, we reported the synthesis of catalase-Fe3O4@ZIF-8 (CAT-Fe3O4@ZIF-8) through a novel amino-acid-boosted one-pot embedding strategy that synergically integrated catalase and magnetic Fe3O4 nanoparticles with ZIF-8. As expected, CAT-Fe3O4@ZIF-8 exhibited enhanced catalytic activity compared …

kidney releases a non-polymerizing form of Uromodulin in the urine and circulation that retains the external hydrophobic patch domain

February 6, 2022 0 Comments

It is released by cells of the thick ascending limbs (TAL) apically in the urine, and basolaterally in the renal interstitium and systemic circulation. Processing of mature urinary THP, which polymerizes into supra-molecular filaments, requires cleavage of an external hydrophobic patch (EHP) at the C-terminus. However, THP in the circulation is not polymerized, and it …

Hologic Panther Fusion Controls

June 28, 2021 0 Comments

The Panther Fusion SARS-CoV-2 Assay is a real-time RT-PCR in vitro diagnostic test intended for the qualitative detection of RNA from SARS-CoV-2 isolated and purified from nasopharyngeal (NP) and oropharyngeal (OP) swab specimens obtained from individuals who meet COVID-19 clinical and/or epidemiological criteria. The Panther Fusion SARS-CoV-2 Assay is for use only under Emergency Use …